What is DNA Ligase IV?
- DNA ligase is a specific type of enzyme, a ligase that repairs single-stranded discontinuities in double stranded DNA molecules
- In simple words strands that have double-strand break (a break in both complementary strands of DNA).
- DNA ligase is used in gene cloning to join DNA molecules together.
- A single-strand break, is fixed by a different type of DNA ligase using the complementary strand as a template, but still requires DNA ligase to create the final phosphodiester bond to fully repair the DNA.
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